Supporting information – Text S8: Supplemental analyses of the LXR model A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism
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A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism
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Supporting information – Text S4: Wild-type model parametrisation A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism
Where x are the state variables of the model, i.e. the lipoprotein concentrations in each cell of both grids ( mol / kg), t represents time (hours), are the model parameters, and u are the model inputs of VLDL and HDL production, which are not time dependent but do depend on several model parameters (D, A scale ). The initial conditions, 0 x are defined at t = 0, 0 0 = ) , ( x t x . The mo...
متن کاملSupporting information – Text S2: Wild-type model equations A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism
Model structure and boundaries The sub-models are divided into 8 by 40 and 40 by 8 compartments of lipoprotein composition, which throughout the supplemental material will be referred to as cells. The metabolism of lipoproteins in cell (i ,j) can be described by equation (1) for cells in the HDL grid and by equation (2) if the cell is in the VLDL grid (see equations (9) and (11) in the Main Tex...
متن کاملSupporting information – Text S1: Additional calculations A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism
In this section, we provide the derivation of equation (3) (Main text). The objective of this calculation is to find an equation that defines CE(j). The equation should provide a value of # CE that is independent of i and that leads to a linear increase in the log10(D) in the progression from (imin; jmin) to (imin; jmax). We note that for all other values of i, the increase in log10(D) will the...
متن کاملA Computational Model for the Analysis of Lipoprotein Distributions in the Mouse: Translating FPLC Profiles to Lipoprotein Metabolism
Disturbances of lipoprotein metabolism are recognized as indicators of cardiometabolic disease risk. Lipoprotein size and composition, measured in a lipoprotein profile, are considered to be disease risk markers. However, the measured profile is a collective result of complex metabolic interactions, which complicates the identification of changes in metabolism. In this study we aim to develop a...
متن کاملSupporting information – Text S5: Wild-type model analysis A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism
A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism Following parameter estimation and evaluation, two parameter sets were found to describe the data well (these will be referred to as sets X1 and X2). Inspection of the in silico FPLC profiles (e.g. Figure 1 in Text S4) reveals that in the VLDL and LDL size range,...
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